Dehydroepiandrosterone, Its Sulfate and Cognitive Functions

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Dehydroepiandrosterone, Its Sulfate and Cognitive Functions

UNLABELLED To present a review of cross-sectional and longitudinal studies that investigate the relationship between the hormones Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone sulfate (DHEA-S) and cognition. METHODS The cognition items included in this review were global cognitive function, memory, attention, executive function, intelligence, perception and visuospatial ability. A ...

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Serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism.

BACKGROUND Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to have protective effects against cardiovascular disease, cancer, immune-modulated diseases, and aging. We examined serum concentrations of DHEA, DHEA-S, and pregnenolone sulfate (PREG-S) in patients with thyroid dysfunction. METHODS Steroids extracted with methanol from serum sample were...

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Metabolism of dehydroepiandrosterone sulfate and estrone-sulfate by human platelets.

The aim of the present research was to study the uptake of DHEAS, and to establish the intracrine capacity of human platelets to produce sex steroid hormones. The DHEAS transport was evaluated through the uptake of [(3)H]-DHEAS in the presence or absence of different substrates through the organic anion transporting polypeptide (OATP) family. The activity of sulfatase enzyme was evaluated, and ...

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Dehydroepiandrosterone Sulfate and Breast Cancer Risk1

It has been suggested that dehydroepiandrosterone (DHEA) and its sulfate ester, dehydroepiandrosterone sulfate (DHEAS), have a protec tive effect against breast cancer. In our investigation, DHEAS levels were measured in plasma obtained and frozen in 1972-1974 from 534 women aged 50-79 yr. This group, which has been followed for 15 yr, included 21 incident cases of breast cancer, 20 cases with ...

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A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly.

The objective of this study was to investigate the relation between the peripheral concentrations of the adrenal steroid hormones cortisol and dehydroepiandrosterone sulfate (DHEAS) and cognitive impairment and decline. A prospective study design was used. The setting was a suburb of Rotterdam, The Netherlands. The study population consisted of a sample of 189 healthy participants from the popu...

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ژورنال

عنوان ژورنال: Clinical Practice & Epidemiology in Mental Health

سال: 2016

ISSN: 1745-0179

DOI: 10.2174/1745017901612010024